化学化工学院
化学生物学系

王平
副教授2
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王平   长聘(教轨)副教授

办公电话:021-54743264

电子邮件:wangp1@sjtu.edu.cn

通讯地址:上海市东川路800号 化学B楼228   


教育背景   

1996-2000:   南京大学化学系,学士   

2000-2005:   中国科学院上海有机化学研究所,博士,导师:俞飚 研究员   


工作经历   

2005-2008:   美国伯纳姆医学研究所,博士后,导师: Peter H.Seegerber 教授   

2008-2013:   纪念斯隆凯特琳癌症中心,博士后、资深研究科学家,导师: Samuel J.Danishefsky 教授   

2013-2016.2:   波士顿WARP DRIVE BIO 生物技术公司,研究科学家   

2016.3- :   上海交通大学化学化工学院,特别研究员   


研究方向   

1)化学合成具有重要生理活性的糖蛋白、糖肽   

2)糖类分子合成及其方法学研究   

3)多肽合成方法学研究   


代表性论文专著   

1.       Wang, S.; Zhou, Q.; Chen, X.; Luo, R.-H.; Li, Y.; Liu, X.; Yang, L.-M.; Zheng, Y.-T.; Wang, P., Modification of N-Terminal α-Amine of Proteins via Biomimetic ortho-quinone-mediated Oxidation. Nat. Commun. 2021, 10.1038/s41467-021-22654-7.   

2.       Ye, F.; Zhao, J.; Xu, P.; Liu, X.; Yu, J.; Shangguan, W.; Liu, J.; Luo, X.; Li, C.; Ying, T.; Wang, J.; Yu, B.; Wang, P., Synthetic Homogeneous Glycoforms of the SARS-CoV-2 Spike Receptor-Binding Domain Reveals Different Binding Profiles of Monoclonal Antibodies. Angew. Chem. Int. Ed. 2021, doi.org/10.1002/ anie.202100543.   

3.       Li, Y.; Liu, J.; Zhou, Q.; Zhao, J.; Wang, P., The preparation of peptide selenoesters from their corresponding acyl hydrazides. Chin. J. Chem. 2021, doi.org/10.1002/cjoc.202100086. Invited Article.   

4.       Yin, H.;   Zheng, M.;   Chen, H.;   Wang, S.;   Zhou, Q.;   Zhang, Q.; Wang, P., Stereoselective and Divergent Construction of β-Thiolated/Selenolated Amino Acids via Photoredox-Catalyzed Asymmetric Giese Reaction. J. Am. Chem. Soc. 2020, 142, 14201-14209.   

5.       Chen, X.;   Luo, X.;   Peng, X.;   Guo, J.;   Zai, J.; Wang, P., Catalyst-Free Decarboxylation of Carboxylic Acids and Deoxygenation of Alcohols by Electro-Induced Radical Formation. Chem. Eur. J. 2020, 26, 3226- 3230.   

6.       Chen, X.;   Luo, X.;   Wang, K.;   Liang, F.; Wang, P., Late-Stage Alkylation of N-Containing Heteroarenes Enabled by Homolysis of Alkyl-1,4-dihydropyridines under Blue LED Irradiation. Synlett 2020, 31, A-E.   

7.       Lu, D.;   Wang, S.;   Yin, H.;   Chu, F.;   Wei, Q.; Wang, P., Rapid Assembly of Oligosaccharides by Using a Hydrophobic Tag-Assisted Liquid-Phase Method. Synlett 2020, 31, 1163-1166.   

8.       Lu, D.;   Yin, H.;   Wang, S.;   Tang, F.;   Huang, W.; Wang, P., Chemical Synthesis of the Homogeneous Granulocyte-Macrophage Colony-Stimulating Factor Through Se-Auxiliary-Mediated Ligation. J. Org. Chem. 2020, 85, 1652-1660. Invited Article.   

9.       Chen, X.;   Ye, F.;   Luo, X.;   Liu, X.;   Zhao, J.;   Wang, S.;   Zhou, Q.;   Chen, G.; Wang, P., Histidine-Specific Peptide Modification via Visible-Light-Promoted C–H Alkylation. J. Am. Chem. Soc. 2019, 141, 18230-18237. Highlighted by Chin. J. Org. Chem and Synfacts.       

10.     Liu, X.;   Liu, J.;   Wu, Z.;   Chen, L.;   Wang, S.; Wang, P., Photo-cleavable purification/protection handle assisted synthesis of giant modified proteins with tandem repeats. Chem. Sci. 2019, 10, 8694-8700.   

11.     Wang, K.;   Chen, X.;   Peng, X.;   Wang, P.; Liang, F., A highly selective H/D exchange reaction of 1,4-dihydropyridines. Org. Biomol. Chem. 2019, 17, 3845-3852.   

12.     Wang, S.;   Thopate, Y. A.;   Zhou, Q.; Wang, P., Chemical Protein Synthesis by Native Chemical Ligation and Variations Thereof. Chin. J. Chem. 2019, 37, 1181-1193. Invited Review.   

13.     Ye, J.;   Xia, H.;   Sun, N.;   Liu, C.-C.;   Sheng, A.;   Chi, L.;   Liu, X.-W.;   Gu, G.;   Wang, S.-Q.;   Zhao, J.;   Wang, P.;   Xiao, M.;   Wang, F.; Cao, H., Reprogramming the enzymatic assembly line for site-specific fucosylation. Nat. Catal. 2019, 2, 514-522.   

14.     Yin, H.;   Lu, D.;   Wang, S.; Wang, P., Development of Powerful Auxiliary-Mediated Ligation To Facilitate Rapid Protein Assembly. Org. Lett. 2019, 21, 5138-5142. Highlighted by Synfacts.   

15.     Luo, H.;   Yin, H.;   Tang, C.;   Wang, P.; Liang, F., Synthesis of cyclic peptide reniochalistatin E and conformational isomers. Chin. Chem. Lett. 2018, 29, 1143-1146.    Before 2018   

16.     Ping Wang, Suwei Dong, Jaehung Shieh, Ronald C. Hendrickson, Malcolm A. Moore, Samuel J. Danishefsky. Erythropoietin Derived by Chemical Synthesis. Science. 2013, 342, 1357-1360.   

17.     Rebecca M. Wilson, Suwei Dong, Ping Wang and Samuel J. Danishefsky. The Winding Pathway to Erythropoietin: Success At Last, Angew. Chem. Int. Ed. 2013, 52.   

18.     Xiaoyu Yang, Ping Wang, Biao Yu. Tacking the challenges in the Total Synthesis of Landomycin A. The Chemical Record. 2013, 13, 70-84.   

19.     Ping Wang, Suwei Dong, Karthik Iyer, John A. Brailsford, Steve D. Townsend, Qiang Zhang, Ronald C. Hendrickson, Jaehung Shieh, Malcolm A. Moore, Samuel J. Danishefsky. At Last: Erythropoietin as a Single Glycoform. Angew. Chem. Int. Ed. 2012, 51, 11576–11584. (Cover of the Journal, Highlighted by Science, Nature, Angew. Chem. Int. Ed., Chemistry World, Chemistry Views, C&EN NEWS)   

20.     Ping Wang, Baptiste Aussedat, Yusuf Vohra and Samuel J. Danishefsky. An Advance in the Chemical Synthesis of Homogeneous N-Linked Glycopolypeptides by Convergent Aspartylation. Angew. Chem. Int. Ed. 2012, 51, 11571–11575.   



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